Endocrine Abstracts

Background: Endoscopic surgery (ES) performed in Pituitary Centers of Excellence (PCOE) represents the gold standard treatment for GH-secreting adenomas. However, rate of cure greatly varies according to definition criteria, follow-up duration, various patient and adenoma features, and surgeon ability.Study aim: To assess short- (3 month) and long-term (≥1 year) outcome and identify predictors of ES, in a large and homogeneous cohort of acromegaly ...

Rationale and aim: The incidence of intracranial aneurysms (IA) appears increased in patients with PAs/PitNETs. Changes in hemodynamics and vascular structure secondary to mass effect, inflammation, and hormonal changes (primarily, GH hypersecretion) have been suggested as risk factors. Study aim was to define typical features, timing of occurrence and treatment, and identify risk factors in patients with PA/PitNET and IA.Patients and methods: Data of 57...

Background: In vitro and animal experiments have clearly demonstrated that excessive cortisol, GH and prolactin secretion, as well as dopamine agonists (D2As) and somatostatin analogs (SSAs), often prescribed for their treatment, affect the immune response and the onset/evolution of autoimmune diseases (AIDs) through direct and indirect complex mechanisms. Data from clinical studies are very scanty.Study aim: To assess the 1) distribution of AIDs accordi...